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Sulfamethazine 99% - 25 Gr - Sigma

Código: 15461

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Sulfamethazine

99.0-101.0% (on dried basis)

Sinônimo(s):

4,6-Dimethylsulfadiazine, 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide, Sulfadimethyldiazine, Sulfadimidine

Empirical Formula (Hill Notation):

C12H14N4O2S

Número CAS:

57-68-1

Peso molecular:

278.33

Beilstein:

261304

Número EC:

200-346-4

Número MDL:

MFCD00006066

ID de substância PubChem:

24899686

NACRES:

NA.85

Nível de qualidade

200

Ensaio

99.0-101.0% (on dried basis)

forma

powder or crystals

condição de armazenamento

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

cor

white to off-white

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria

Modo de ação

DNA synthesis | interferes
enzyme | inhibits

temperatura de armazenamento

2-8°C

SMILES string

Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1

InChI

1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)

InChI key

ASWVTGNCAZCNNR-UHFFFAOYSA-N

Descrição geral

Chemical structure: sulfonamide

Aplicação

Sulfamethazine is an antibiotic used to treat bronchitis, prostatitis and urinary tract infections[1]. It is used in disposition and depletion kinetic studies[2][3]. It is used to develop detection techniques for quantification in fluids such as cows′ milk, honey and swine urine[4].

Ações bioquímicas/fisiológicas

Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[1]. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.

An antimicrobial sulfur drug. Induces CYP3A4 expression and acetylated by N-acetyltransferase. Exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11.

Embalagem

25G,100G

Outras notas

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

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