Sulfamethazine 99% - 25 Gr - Sigma
Código: 15461
Sulfamethazine
99.0-101.0% (on dried basis)
Sinônimo(s):
4,6-Dimethylsulfadiazine, 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide, Sulfadimethyldiazine, Sulfadimidine
Empirical Formula (Hill Notation):
C12H14N4O2S
Número CAS:
Peso molecular:
278.33
Beilstein:
261304
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.85
Nível de qualidade
Ensaio
99.0-101.0% (on dried basis)
forma
powder or crystals
condição de armazenamento
(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
cor
white to off-white
espectro de atividade do antibiótico
Gram-negative bacteria
Gram-positive bacteria
Modo de ação
DNA synthesis | interferes
enzyme | inhibits
temperatura de armazenamento
2-8°C
SMILES string
Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1
InChI
1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)
InChI key
ASWVTGNCAZCNNR-UHFFFAOYSA-N
Descrição geral
Chemical structure: sulfonamide
Aplicação
Sulfamethazine is an antibiotic used to treat bronchitis, prostatitis and urinary tract infections[1]. It is used in disposition and depletion kinetic studies[2][3]. It is used to develop detection techniques for quantification in fluids such as cows′ milk, honey and swine urine[4].
Ações bioquímicas/fisiológicas
Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[1]. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.
An antimicrobial sulfur drug. Induces CYP3A4 expression and acetylated by N-acetyltransferase. Exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11.
Embalagem
25G,100G
Outras notas
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.