GBR 12909 dihydrochloride

solid, ≥98% (HPLC)

Sinônimo(s):

1-(2-[bis(4-Fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride

Empirical Formula (Hill Notation):

C₂₈H₃₂F₂N₂O · 2HCl

Número CAS:

67469-78-7

Peso molecular:

523.49

Número MDL:

MFCD00055193

ID de substância PubChem:

24277909

NACRES:

NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

cor

white

solubilidade

DMSO: >5 mg/mL (Solutions freshly prepared daily)

SMILES string

Cl.Cl.Fc1ccc(cc1)C(OCCN2CCN(CCCc3ccccc3)CC2)c4ccc(F)cc4

InChI

1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H

InChI key

MIBSKSYCRFWIRU-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

Aplicação

GBR 12909 dihydrochloride has been used as a dopamine transporter (DAT) inhibitor:

to study its effects on LPS-induced mRNA expression on the proinflammatory cytokines in the mouse striatum[1]

to study its effects on neurotransmitter release in zebrafish brain[2]

in DA uptake assay in mice striatal fraction[3]

Ações bioquímicas/fisiológicas

GBR 12909 may show pharmacotherapeutic effects against cocaine addiction.[4]

GBR 12909 is a highly selective dopamine reuptake inhibitor with behavioral effects similar to cocaine.

Características e benefícios

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.