GBR 12909 Dihydrochloride Solid >= 98% Hplc - 100 Mg - Sigma
Código: 16713
GBR 12909 dihydrochloride
solid, ≥98% (HPLC)
Sinônimo(s):
1-(2-[bis(4-Fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
Empirical Formula (Hill Notation):
C28H32F2N2O · 2HCl
Número CAS:
Peso molecular:
523.49
Número MDL:
ID de substância PubChem:
NACRES:
NA.77
Nível de qualidade
Ensaio
≥98% (HPLC)
forma
solid
cor
white
solubilidade
DMSO: >5 mg/mL (Solutions freshly prepared daily)
SMILES string
Cl.Cl.Fc1ccc(cc1)C(OCCN2CCN(CCCc3ccccc3)CC2)c4ccc(F)cc4
InChI
1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
InChI key
MIBSKSYCRFWIRU-UHFFFAOYSA-N
Gene Information
human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)
Aplicação
GBR 12909 dihydrochloride has been used as a dopamine transporter (DAT) inhibitor:
to study its effects on LPS-induced mRNA expression on the proinflammatory cytokines in the mouse striatum[1]
to study its effects on neurotransmitter release in zebrafish brain[2]
in DA uptake assay in mice striatal fraction[3]
Ações bioquímicas/fisiológicas
GBR 12909 may show pharmacotherapeutic effects against cocaine addiction.[4]
GBR 12909 is a highly selective dopamine reuptake inhibitor with behavioral effects similar to cocaine.
Características e benefícios
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.