2,6-Di-Tert-Butyl-4-Methylphenol - 500 Gr - Sigma
Código: 17111
2,6-Di-tert-butyl-4-methylphenol
≥99.0% (GC), powder
Synonym: 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC
- CAS Number 128-37-0
- Linear Formula [(CH3)3C]2C6H2(CH3)OH
- Molecular Weight 220.35
- Beilstein/REAXYS Number 1911640
- EC Number 204-881-4
- MDL number MFCD00011644
- PubChem Substance ID 57653920
- NACRES NA.22
|
vapor density |
7.6 (vs air) |
|
vapor pressure |
|
|
assay |
≥99.0% (GC) |
|
form |
powder |
|
autoignition temp. |
878 °F |
|
bp |
265 °C (lit.) |
|
mp |
69-73 °C (lit.) |
|
solubility |
ethanol: 100 mg/mL |
|
|
vegetable oils: soluble |
|
storage temp. |
room temp |
|
SMILES string |
Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C |
|
InChI |
1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3 |
|
InChI key |
NLZUEZXRPGMBCV-UHFFFAOYSA-N |
|
Gene Information |
Descrição
Packaging
1 kg in poly bottle
100, 500 g in poly bottle
Biochem/physiol Actions
Butylated hydroxytoluene (BHT) is a phenolic antioxidant. It has been shown to inhibit lipid peroxidation. It causes lung injury and promotes tumors in mice, but this may be due to a metabolite of BHT, 6-tert-butyl-2-[2′-(2′-hydroxymethyl)-propyl]-4-methylphenol. Metabolites of BHT have also been reported to induce DNA strand breaks and internucleosomal DNA fragmentation (a characteristic of apoptosis) in cultured cells. In rats, a single intraperitoneal injection of BHT (60 mg/kg body mass) results in a significant increase in nuclear DNA methyl transferase activity in the liver, kidneys, heart, spleen, brain and lungs. Incubation of alveolar macrophages with BHT significantly reduced the level of TNF-α which may explain the mechanism by which this antioxidant reduces inflammation. Preincubation of aspirin-treated platelets with BHT inhibits the secretion, aggregation, and protein phosphorylation induced by protein kinase C activators. BHT was also found to inhibit the initiation of hepatocarcinogenesis by aflatoxin B1.
