1,8-Diazabicyclo [5.4.0] Undec-7-Ene 985 - 25 Gr - Sigma
Código: 17697
1,8-Diazabicyclo[5.4.0]undec-7-ene 98%
Sinônimo(s):
2,3,4,6,7,8,9,10-Octahydropyrimidol[1,2-a]azepine, DBU
Empirical Formula (Hill Notation):
C9H16N2
Peso molecular:
152.24
Beilstein:
508906
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.22
pressão de vapor
5.3 mmHg ( 37.7 °C)
Nível de qualidade
200
teor
98%
forma
liquid
características do produto alternativo mais ecológico
Catalysis
Learn more about the Principles of Green Chemistry.
índice de refração
n20/D 1.522-1.524 (lit.)
pb
80-83 °C/0.6 mmHg (lit.)
densidade
1.018 g/mL at 25 °C (lit.)
categoria alternativa mais ecológica
Aligned
SMILES string
C1CCN2CCCN=C2CC1
InChI
1S/C9H16N2/c1-2-5-9-10-6-4-8-11(9)7-3-1/h1-8H2
InChI key
GQHTUMJGOHRCHB-UHFFFAOYSA-N
Descrição geral
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for catalytic efficiency. Click here for more information.
1,8-Diazabicyclo[5.4.0]undec-7-ene is a bicyclic amidine base. It is non-nucleophilic, sterically hindered, tertiary amine base in organic chemistry. It is reported to be superior to amine catalyst in Baylis-Hillman reaction. It promotes the methylation reaction of phenols, indoles and benzimidazoles with dimethyl carbonate under mild conditions.
Aplicação
Used in a new synthesis of the ABCD ring system of Camptothecin.
1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) may be used:
as catalyst for carboxylic acid esterification with dimethyl carbonate
in the synthesis of duocarmycin and CC-1065 analogs
as catalyst in aza-Michael addition and Knovenegal condensation reaction
as base for dehalogenation of halogenated Diels-Alder adducts and the resulting activated 2,4-dienones were subjected to regio- and stereo-directed Michael additions, using Yamamoto′s reagent (CH3Cu · BF3)
in a new synthesis of the ABCD ring system of Camptothecin
1,8-Diazabicyclo[5.4.0]undec-7-ene may be used as an catalyst for the dissolution and activation of cellulose by a reversible reaction of its hydroxyl groups with carbon dioxide. This dissolved cellulose system can be derivatized to form cellulose mixed esters.
Embalagem
25, 100, 500 g in glass bottle
2.5 kg in glass bottle
Características e benefícios
Strong hindered amine base.
Citação
An application review.