Diclofenaco De Sódio (Diclofenac Sodium Salt) 98% (TLC) - 10 Gr - Sigma

Diclofenac sodium salt

Sinônimo(s):

2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt

Empirical Formula (Hill Notation):

C₁₄H₁₀Cl₂NNaO₂

Número CAS:

15307-79-6

Peso molecular:

318.13

Número EC:

239-346-4

Número MDL:

MFCD00082251

ID de substância PubChem:

24277712

NACRES:

NA.77

fonte biológica

synthetic

teor

≥98% (TLC)

forma

powder

pf

283-285  °C

solubilidade

methanol: 50 mg/mL, clear, colorless to faint yellow or tan

originador

Novartis

temperatura de armazenamento

room temp

SMILES string

[Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl

InChI

1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1

InChI key

KPHWPUGNDIVLNH-UHFFFAOYSA-M

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

Aplicação

Diclofenac sodium has been used:

to investigate its radioprotective potential in a study

to determine the basic viscosity and hydrodynamic values of the solubilizers and their micellar adducts in a study

as a standard for potentiometric and fluorimetric determination of diclofenac in a sequential injection analysis system

to inhibit phase II drug metabolizing enzyme (DME) in a study to investigate the inhibitory effects of an ethanol extract of Descurainia sophia seeds on Phase I and II DMEs

Ações bioquímicas/fisiológicas

Diclofenac sodium salt is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a competitive and irreversible inhibitor of prostaglandin synthetase. Its analgesic and anti-inflammatory activities are based on the prevention of the synthesis of arachinodate metabolites via cyclooxygenase inhibition. It is found to hinder the conversion of arachidonic acid to prostaglandins, which mediate inflammatory process. The NSAIDs are found to inhibit both cyclooxygenase enzymes, COX-1 and COX-2, causing undesirable gastrointestinal effect. Diclofenac sodium also functions as a scavenger of free radicals and serves a radioprotective role in restoring supercoiled form of plasmid DNA damaged by radiation back to normal. Diclofenac sodium is oxidized by the donation of electron and transfer of hydrogen atom. It can be a potential radioprotective agent.

Standard NSAID and cyclooxygenase (COX) inhibitor. Major metabolites are 4´-hydroxydiclofenac and 5´-hydroxydiclofenac. Has been used as substrate selective for CYP2C9.

Características e benefícios

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.