Diclofenaco De Sódio (Diclofenac Sodium Salt) 98% (TLC) - 25 Gr - Sigma
Código: 17816
Diclofenaco De Sódio (Diclofenac Sodium Salt) 98% (TLC) - 10 Gr - Sigma
Diclofenac sodium salt
Sinônimo(s):
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
Empirical Formula (Hill Notation):
C14H10Cl2NNaO2
Número CAS:
Peso molecular:
318.13
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.77
fonte biológica
synthetic
teor
≥98% (TLC)
forma
powder
pf
283-285 °C
solubilidade
methanol: 50 mg/mL, clear, colorless to faint yellow or tan
originador
Novartis
temperatura de armazenamento
room temp
SMILES string
[Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
InChI
1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
InChI key
KPHWPUGNDIVLNH-UHFFFAOYSA-M
Gene Information
human ... PTGS1(5742) , PTGS2(5743)
Aplicação
Diclofenac sodium has been used:
to investigate its radioprotective potential in a study
to determine the basic viscosity and hydrodynamic values of the solubilizers and their micellar adducts in a study
as a standard for potentiometric and fluorimetric determination of diclofenac in a sequential injection analysis system
to inhibit phase II drug metabolizing enzyme (DME) in a study to investigate the inhibitory effects of an ethanol extract of Descurainia sophia seeds on Phase I and II DMEs
Ações bioquímicas/fisiológicas
Diclofenac sodium salt is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a competitive and irreversible inhibitor of prostaglandin synthetase. Its analgesic and anti-inflammatory activities are based on the prevention of the synthesis of arachinodate metabolites via cyclooxygenase inhibition. It is found to hinder the conversion of arachidonic acid to prostaglandins, which mediate inflammatory process. The NSAIDs are found to inhibit both cyclooxygenase enzymes, COX-1 and COX-2, causing undesirable gastrointestinal effect. Diclofenac sodium also functions as a scavenger of free radicals and serves a radioprotective role in restoring supercoiled form of plasmid DNA damaged by radiation back to normal. Diclofenac sodium is oxidized by the donation of electron and transfer of hydrogen atom. It can be a potential radioprotective agent.
Standard NSAID and cyclooxygenase (COX) inhibitor. Major metabolites are 4´-hydroxydiclofenac and 5´-hydroxydiclofenac. Has been used as substrate selective for CYP2C9.
Características e benefícios
This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.