Penicillin - Streptomycin Solution Stabilized 100 Ml - Sigma
Código: 19857
Penicilina-estreptomicina
Solution Stabilized, with 5,000 units penicillin and 5mg streptomycin/mL, 0.1 μm filtered, BioReagent, suitable for cell culture
Sinônimo(s):
Pen-Strep
NACRES:
NA.76
Nível de qualidade
esterilidade
0.1 μm filtered
linha de produto
BioReagent
forma
liquid
concentração
50 ×
technique(s)
cell culture | mammalian: suitable
Impurezas
endotoxin, tested
espectro de atividade do antibiótico
Gram-negative bacteria
Gram-positive bacteria
Modo de ação
cell wall synthesis | interferes
protein synthesis | interferes
enviado em
dry ice
temperatura de armazenamento
−20°C
SMILES string
CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(O)=O.CNC[C@H]4[C@H](O)[C@@H](O)[C@H](CCO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)C5(O)C=O)O[C@H]6[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]6NC(N)=N
InChI
1S/C23H43N7O12.C16H18N2O4S/c1-7-23(38,6-32)18(42-19-8(5-28-2)12(33)13(34)9(40-19)3-4-31)20(39-7)41-17-11(30-22(26)27)14(35)10(29-21(24)25)15(36)16(17)37;1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h6-20,28,31,33-38H,3-5H2,1-2H3,(H4,24,25,29)(H4,26,27,30);3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t7-,8-,9-,10+,11-,12-,13-,14+,15-,16+,17+,18-,19-,20-,23+;11-,12+,14-/m01/s1
InChI key
KMOOCZWLFBSQCW-XFOLRDBHSA-N
Descrição geral
Penicillin, a β-lactam antibiotic is extremely active towards bacteria.[1] Penicillins are also termed as penams. It is naturally occurring and has a bicyclic skeleton.[2] Streptomycin is a pseudotrisaccharide. It comprises of a monosubstituted aminocyclitol.[3]
Aplicação
Penicillin-Streptomycin has been used:
as a supplement in Dulbecco′s modified Eagle′s medium (DMEM) to maintain the Huh7 liver hepatoma cell line[4]
as a supplement in Roswell park memorial institute-1640 (RPMI) medium to maintain mouse lymphoma YAC-1 cells[5]
as a component in minimum essential medium Eagle to treat individual mouse spleens for the preparation of splenocytes[6]
as a supplement in FMX-8 complete medium to culture Chinese hamster ovary cells[7]
Recommended for use in cell culture media at 20 ml/L.
Ações bioquímicas/fisiológicas
Penicillins can prevent the synthesis of bacterial cell wall. This antibiotic can be used in the treatment of skin and urinary tract infections, upper and lower respiratory infections, and endocarditis.[8] Streptomycin can block Mycobacterium tuberculosis in vitro.[4] Streptomycin inhibits prokaryote protein synthesis[7] by preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding.
Componentes
This product is formulated to contain 5,000 units penicillin and 5 mg streptomycin/mL solubilized in a proprietary citrate buffer.
Outras notas
20ml,100ml
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.