Penicilina-estreptomicina

Solution Stabilized, with 5,000 units penicillin and 5mg streptomycin/mL, 0.1 μm filtered, BioReagent, suitable for cell culture

Sinônimo(s):

Pen-Strep

NACRES:

NA.76

Nível de qualidade

300

esterilidade

0.1 μm filtered

linha de produto

BioReagent

forma

liquid

concentração

50 ×

technique(s)

cell culture | mammalian: suitable

Impurezas

endotoxin, tested

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria

Modo de ação

cell wall synthesis | interferes
protein synthesis | interferes

enviado em

dry ice

temperatura de armazenamento

−20°C

SMILES string

CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(O)=O.CNC[C@H]4[C@H](O)[C@@H](O)[C@H](CCO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)C5(O)C=O)O[C@H]6[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]6NC(N)=N

InChI

1S/C23H43N7O12.C16H18N2O4S/c1-7-23(38,6-32)18(42-19-8(5-28-2)12(33)13(34)9(40-19)3-4-31)20(39-7)41-17-11(30-22(26)27)14(35)10(29-21(24)25)15(36)16(17)37;1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h6-20,28,31,33-38H,3-5H2,1-2H3,(H4,24,25,29)(H4,26,27,30);3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t7-,8-,9-,10+,11-,12-,13-,14+,15-,16+,17+,18-,19-,20-,23+;11-,12+,14-/m01/s1

InChI key

KMOOCZWLFBSQCW-XFOLRDBHSA-N

Descrição geral

Penicillin, a β-lactam antibiotic is extremely active towards bacteria.[1] Penicillins are also termed as penams. It is naturally occurring and has a bicyclic skeleton.[2] Streptomycin is a pseudotrisaccharide. It comprises of a monosubstituted aminocyclitol.[3]

Aplicação

Penicillin-Streptomycin has been used:

as a supplement in Dulbecco′s modified Eagle′s medium (DMEM) to maintain the Huh7 liver hepatoma cell line[4]

as a supplement in Roswell park memorial institute-1640 (RPMI) medium to maintain mouse lymphoma YAC-1 cells[5]

as a component in minimum essential medium Eagle to treat individual mouse spleens for the preparation of splenocytes[6]

as a supplement in FMX-8 complete medium to culture Chinese hamster ovary cells[7]

 Recommended for use in cell culture media at 20 ml/L.

Ações bioquímicas/fisiológicas

Penicillins can prevent the synthesis of bacterial cell wall. This antibiotic can be used in the treatment of skin and urinary tract infections, upper and lower respiratory infections, and endocarditis.[8] Streptomycin can block Mycobacterium tuberculosis in vitro.[4] Streptomycin inhibits prokaryote protein synthesis[7] by preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding.

Componentes

This product is formulated to contain 5,000 units penicillin and 5 mg streptomycin/mL solubilized in a proprietary citrate buffer.

Outras notas

20ml,100ml

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.