Antimycin A From Streptomyces Sp - 25 Mg - Sigma
Código: 20184
Antimycin A from Streptomyces sp.
Número CAS:
Número MDL:
ID de substância PubChem:
NACRES:
NA.77
forma
powder
Nível de qualidade
espectro de atividade do antibiótico
fungi
Modo de ação
enzyme | inhibits
temperatura de armazenamento
−20°C
SMILES string
[H]C(=O)Nc1cccc(C(=O)N[C@H]2[C@@H](C)OC(=O)C(CCCCCC)[C@@H](OC(=O)CC(C)C)[C@H](C)OC2=O)c1O
InChI
1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20?,23+,25+/m1/s1
InChI key
UIFFUZWRFRDZJC-RBVQMQRASA-N
Descrição geral
Antimycin is produced by Streptomyces species. [1] It inhibits mitochondrial electron transport chain complex III and favors reactive oxygen species (ROS) production, impairing mitochondrial depolarization.[2] It inhibits nitric oxide-mediated apoptosis and modulatescytochrome C release.[3] It suppresses tumorigenesis in lung cancer cells and could be a potential therapeutic agent.[4]
Chemical structure: peptide
Aplicação
Antimycin A from Streptomyces sp. has been used:
as a respiratory chain inhibitor in neuronal cultures[5][6]
in organello ATP production assay in Trypanosoma brucei cells[7]
in respiration assay for papillary thyroid carcinoma (PTC) cell lines[8]
Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise
Ações bioquímicas/fisiológicas
Inhibitor of electron transfer at complex III. Induces apoptosis.
Qualidade
A mixture of antimycins.