Antimycin A from Streptomyces sp.

Número CAS:

1397-94-0

Número MDL:

MFCD01779723

ID de substância PubChem:

24891355

NACRES:

NA.77

forma

powder

Nível de qualidade

300

espectro de atividade do antibiótico

fungi

Modo de ação

enzyme | inhibits

temperatura de armazenamento

−20°C

SMILES string

[H]C(=O)Nc1cccc(C(=O)N[C@H]2[C@@H](C)OC(=O)C(CCCCCC)[C@@H](OC(=O)CC(C)C)[C@H](C)OC2=O)c1O

InChI

1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20?,23+,25+/m1/s1

InChI key

UIFFUZWRFRDZJC-RBVQMQRASA-N

Descrição geral

Antimycin is produced by Streptomyces species. [1] It inhibits mitochondrial electron transport chain complex III and favors reactive oxygen species (ROS) production, impairing mitochondrial depolarization.[2] It inhibits nitric oxide-mediated apoptosis and modulatescytochrome C release.[3] It suppresses tumorigenesis in lung cancer cells and could be a potential therapeutic agent.[4]

Chemical structure: peptide

Aplicação

Antimycin A from Streptomyces sp. has been used:

as a respiratory chain inhibitor in neuronal cultures[5][6]

in organello ATP production assay in Trypanosoma brucei cells[7]

in respiration assay for papillary thyroid carcinoma (PTC) cell lines[8]

Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise

Ações bioquímicas/fisiológicas

Inhibitor of electron transfer at complex III. Induces apoptosis.

Qualidade

A mixture of antimycins.