Ácido Rosmarínico (Rosmarinic Acid) 98% (HPLC) - 10 Mg - Sigma
Código: 21445
Ácido Rosmarínico (Rosmarinic Acid) ≥98% (HPLC), from Rosemarinus officinalis L.
Sinônimo(s):
(R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid, 3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl ester
Fórmula empírica (Notação de Hill):
C18H16O8
Número CAS:
Peso molecular:
360.31
Beilstein:
2227587
Número MDL:
ID de substância PubChem:
fonte biológica
Rosemarinus officinalis L.
Nível de qualidade
Ensaio
≥98% (HPLC)
forma
powder
condição de armazenamento
protect from light
cor
white to faint beige
pf
171-175 °C (lit.)
solubilidade
H2O: 1 mg/mL, clear, colorless
aplicação(ões)
metabolomics
vitamins, nutraceuticals, and natural products
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2
InChI
1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1
chave InChI
DOUMFZQKYFQNTF-WUTVXBCWSA-N
Descrição geral
Rosmarinic acid is a naturally occurring polyphenolic compound found in plants of the Boraginaceae family and Nepetoideae subfamily. It is an ester of caffeic acid as well as 3,4-dihydroxy-phenyllactic acid.[1]
Aplicação
Rosmarinic acid has been used:
-
to see its protective effects on the human endothelial cell line (EA.hy926) to treat diabetic atherosclerosis[2]
-
to test its effect in 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) induced Parkinson′s disease (PD) models on attenuating inflammatory responses and microglia activation[3]
-
to test its neuroprotective effects on dopaminergic neurons[4]
-
to test its effects on sperm motility, viability and on intracellular calcium ion concentration[5]
-
as a reference standard in capillary zone electrophoresis (CZE) method[6]
Ações bioquímicas/fisiológicas
Rosmarinic acid (RosA) is a well-appreciated agent used in several diabetic conditions and complications such as diabetic nephropathy, diabetic neuropathy and diabetic atherosclerosis.[2] It has also been implicated to be a neuroprotective agent for several neurological disorders such as Alzheimer′s disease, Parkinson′s disease, and epilepsy by suppressing their conditions.[7][3][4]