8-Hydroxy-2′-deoxyguanosine ≥98% (TLC)

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Sinônimo(s):

8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG

Fórmula empírica (Notação de Hill):

C₁₀H₁₃N₅O₅

Número CAS:

88847-89-6

Peso molecular:

283.24

Número MDL:

MFCD00210311

Código UNSPSC:

12352200

ID de substância PubChem:

24895702

NACRES:

NA.77

Nível de qualidade

200

Ensaio

≥98% (TLC)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O=C1C(NC(N2C3CC(O)C(CO)O3)=O)=C2NC(N)=N1

InChI

1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)

chave InChI

HCAJQHYUCKICQH-UHFFFAOYSA-N

Aplicação

8-Hydroxy-2′-deoxyguanosine has been used:

• as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection[1]

• as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement[2]

• as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential antioxidant activity of green coffee bean extract (GCBE) in vivo[3]

• as a standard for LC/MS/MS analysis[4]

Ações bioquímicas/fisiológicas

A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis

The levels of 8-hydroxy-2′-deoxyguanosine helps in evaluating oxidative stress and DNA damage in individuals suffering from laryngeal cancer.[5] Hence it serves as a major biomarker of DNA damage, induced by reactive oxygen species (ROS).[6]