8-Hydroxy-2'-Deoxyguanosine 98% (TLC) - 5 Mg - Sigma
Código: 21703
8-Hydroxy-2′-deoxyguanosine ≥98% (TLC)
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Sinônimo(s):
8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG
Fórmula empírica (Notação de Hill):
C10H13N5O5
Número CAS:
Peso molecular:
283.24
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77
Nível de qualidade
Ensaio
≥98% (TLC)
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
O=C1C(NC(N2C3CC(O)C(CO)O3)=O)=C2NC(N)=N1
InChI
1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)
chave InChI
HCAJQHYUCKICQH-UHFFFAOYSA-N
Aplicação
8-Hydroxy-2′-deoxyguanosine has been used:
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as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection[1]
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as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement[2]
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as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential antioxidant activity of green coffee bean extract (GCBE) in vivo[3]
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as a standard for LC/MS/MS analysis[4]
Ações bioquímicas/fisiológicas
A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis
The levels of 8-hydroxy-2′-deoxyguanosine helps in evaluating oxidative stress and DNA damage in individuals suffering from laryngeal cancer.[5] Hence it serves as a major biomarker of DNA damage, induced by reactive oxygen species (ROS).[6]