Hidrocortisona Bioreagent - 1 Gr - Sigma
Código: 21720
Hidrocortisona BioReagent, suitable for cell culture
Sinônimo(s):
11β,17α,21-Tri-hidroxipregna-4-eno-3,20-diona, 17-Hidroxicorticosterona, 4-Pregneno-11β,17α,21-triol-3,20-diona, Composto F de Kendall, Cortisol, Substância M de Reichstein
Fórmula empírica (Notação de Hill):
C21H30O5
Número CAS:
Peso molecular:
362.46
Beilstein:
1354819
Número CE:
Número MDL:
Código UNSPSC:
12352209
ID de substância PubChem:
NACRES:
NA.77
fonte biológica
plant (wild yam)
Nível de qualidade
linha de produto
BioReagent
Ensaio
≥98%
forma
powder
técnica(s)
cell culture | mammalian: suitable
pf
211-214 °C (lit.)
solubilidade
chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to very faintly yellow
Condições de expedição
ambient
temperatura de armazenamento
room temp
cadeia de caracteres SMILES
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
InChI
1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
chave InChI
JYGXADMDTFJGBT-VWUMJDOOSA-N
Informações sobre genes
human ... ABCB1(5243) , CYP3A4(1576) , NR3C1(2908) , SERPINA6(866)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126)
rat ... Ar(24208) , Nr3c1(24413)
Aplicação
Hydrocortisone has been used as a supplement in culture media for oligodendrocytes, colon cells and epithelial cells.[1][2]
Ações bioquímicas/fisiológicas
Glicocorticoide primário secretado pelo córtex adrenal. Tem três vezes a potência anti-inflamatória da corticosterona, mas uma potência de retenção de Na2+ muito menor.
Hydrocortisone (also referred to as cortisol) is an endogenous glucocorticoid which is secreted by the adrenal gland. It is produced from the hypothalamus–pituitary–adrenal (HPA) axis. Hydrocortisone interacts with glucocorticoid receptors and regulates various signaling pathways. It is associated with the induction of energy mobilization, increase in cerebral perfusion rates and local glucose consumption. It is also linked with increase in cardiovascular output and respiration, redistribution of blood, delivery of molecules and energy to the brain and muscles and modulation of immune responses.[3][4]
forma física
powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw
Reconstituição
To prepare 50 μg/mL stock solution, add 1.0 mL absolute ethanol to 1.0 mg of product, gently swirl to dissolve, add 19 mL sterile medium.