Ortovanadato De Sódio (Sodium Orthovanadate) 90%

Sinônimo(s):

Trisodium vanadate

Fórmula linear:

Na₃VO₄

Número CAS:

13721-39-6

Peso molecular:

183.91

Número CE:

237-287-9

Número MDL:

MFCD00003511

Código UNSPSC:

12352200

ID de substância PubChem:

24899708

NACRES:

NA.77

fonte biológica

synthetic (organic)

Nível de qualidade

200

Ensaio

≥90% (titration)

forma

crystalline powder

adequação da reação

reagent type: catalyst
core: vanadium

cor

white to off-white

pf

850-866 °C (lit.)

solubilidade

H₂O: soluble

cadeia de caracteres SMILES

[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O

InChI

1S/3Na.4O.V/q3*+1;;3*-1;

chave InChI

IHIXIJGXTJIKRB-UHFFFAOYSA-N

Aplicação

Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase.²⁶ It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.²⁷

Ações bioquímicas/fisiológicas

Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.²⁴ In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.²⁵

Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP₃)-induced Ca²⁺ release from endocrine cells and blocks IP₃ binding to its receptor in brain tissue.

Características e benefícios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.