Ortovanadato De Sódio (Sodium Orthovanadate) 90% - 250 Gr - Sigma
Código: 21745
Ortovanadato De Sódio (Sodium Orthovanadate) 90%
Sinônimo(s):
Trisodium vanadate
Fórmula linear:
Na3VO4
Número CAS:
Peso molecular:
183.91
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77
fonte biológica
synthetic (organic)
Nível de qualidade
Ensaio
≥90% (titration)
forma
crystalline powder
adequação da reação
reagent type: catalyst
core: vanadium
cor
white to off-white
pf
850-866 °C (lit.)
solubilidade
H2O: soluble
cadeia de caracteres SMILES
[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O
InChI
1S/3Na.4O.V/q3*+1;;3*-1;
chave InChI
IHIXIJGXTJIKRB-UHFFFAOYSA-N
Aplicação
Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase.26 It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.27
Ações bioquímicas/fisiológicas
Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.24 In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.25
Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release from endocrine cells and blocks IP3 binding to its receptor in brain tissue.
Características e benefícios
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.