Sirtinol 95% (HPLC)

Sinônimo(s):

2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide

About This Item

Fórmula empírica (Notação de Hill):

C₂₆H₂₂N₂O₂

Número CAS:

410536-97-9

Peso molecular:

394.47

Número MDL:

MFCD00810186

Código UNSPSC:

12352203

ID de substância PubChem:

24899771

NACRES:

NA.77

Nível de qualidade

200

Ensaio

≥95% (HPLC)

forma

solid

solubilidade

DMSO: soluble

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CC(NC(=O)c1ccccc1\N=C\c2c(O)ccc3ccccc23)c4ccccc4

InChI

1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30)/b27-17+

chave InChI

UXJFDYIHRJGPFS-WPWMEQJKSA-N

Informações sobre genes

human ... SIRT1(23411) , SIRT2(22933)

Aplicação

HUVEC were treated with sirtinol to study the effect on induction of transcription factor Krüppel-like factor 2.⁴ Sirtinol was used to treat human embryonic kidney cells to study the effect on the expression on Werner syndrome protein.⁵

Ações bioquímicas/fisiológicas

Sirtinol inhibits yeast Sir2p transcriptional silencing activity in vivo, yeast Sir2p and human SIRT2 deacetylase activity in vitro. It inhibits the physiological regulators of platelet aggregation such as thrombin and collagen, attenuates intracellular Ca²⁺ release and formation thromboxane B2. It may increase levels of cAMP by inhibition of cAMP phosphodiesterase and inhibit the aggregation of platelets.² Sirtinol reduces inflammatory responses of human dermal microvascular endothelial cells to TNF-α and IL-1β.³

Sirtinol inhibits yeast Sir2p transcriptional silencing activity in vivo, yeast Sir2p, and human SIRT2 deacetylase activity in vitro.