Kaempferol 90% (HPLC) Powder - 10 Mg – Sigma

Sinônimo(s):

3,4′,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, Robigenin

About This Item

Fórmula empírica (Notação de Hill):

C₁₅H₁₀O₆

Número CAS:

520-18-3

Peso molecular:

286.24

Beilstein:

304401

Número MDL:

MFCD00016938

Código UNSPSC:

12191503

ID de substância PubChem:

24896195

NACRES:

NA.25

fonte biológica

synthetic

Nível de qualidade

100

Ensaio

≥90% (HPLC)

Formulário

powder

condição de armazenamento

protect from light

cor

yellow

pf

277 °C

solubilidade

ethanol: 20 mg/mL
DMSO: 50 mg/mL

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

Oc1ccc(cc1)C2=C(O)C(=O)c3c(O)cc(O)cc3O2

InChI

1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H

chave InChI

IYRMWMYZSQPJKC-UHFFFAOYSA-N

Informações sobre genes

human ... CDC2(983) , CDK5(1020) , CDK6(1021) , CYP1A2(1544) , CYP2C9(1559) , GSK3A(2931)
mouse ... Hexa(15211)

Descrição geral

Kaempferol is a natural dietary flavonoid and a polyphenol antioxidant found in various fruits and vegetables.[1] Kaempferol is present in plants in a different glycosidic form such as astragalin by binding with different sugars.[2]

Aplicação

Chromogenic reagent for antimony in the low ppm range and for gallium and indium in the sub-ppm range.

Kaempferol (KAE) has been used:

• to check its potential effect as an antioxidant and neuroprotective agent against rotenone-induced Parkinson′s disease (PD) model in SH-S5Y5 cells[3]
• to test its anti-inflammatory effect on lipopolysaccharide (LPS)-induced inflammatory injury in human aortic endothelial cells (HAECs)[4]
• to study its apoptosis sensitizing effect on non-small cell lung cancer (NSCLC) cells by inhibiting nuclear factor erythroid 2-related factor 2 (Nrf2)[5]

Ações bioquímicas/fisiológicas

Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.

The diphenylpropane component of Kaempferol contributes to its hydrophobic properties.[2] It has shown to revert the transformed phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH 3T3 cells. Kaempferol induces significant nuclear DNA degradation concurrent with lipid peroxidation.[6] It also inhibits topoisomerase I catalyzed DNA religation.[7] Kaempferol may also inhibit the activity of fatty acid synthase.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.