cis-Diammineplatinum(II) dichloride ≥99.99% (trace metal analysis), crystalline, macrophage activator

Sinônimo(s):

cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin

About This Item

Fórmula linear:

Pt(NH₃)₂Cl₂

CAS Number:

15663-27-1

Peso molecular:

300.05

Número CE:

239-733-8

Número MDL:

MFCD00011623

Código UNSPSC:

12352200

ID de substância PubChem:

24278632

NACRES:

NA.77

Product Name

cis-Diammineplatinum(II) dichloride, crystalline

Formulário

crystalline

Nível de qualidade

200

cor

yellow

pf

270 °C (lit.)

espectro de atividade do antibiótico

neoplastics

Modo de ação

DNA synthesis | interferes

originador

Corden

cadeia de caracteres SMILES

N.N.Cl[Pt]Cl

InChI

1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

chave InChI

LXZZYRPGZAFOLE-UHFFFAOYSA-L

Aplicação

cis-Diammineplatinum(II) dichloride has been used:

in cell viability measurement in cochlear explants[1]

in the inhibition of cell proliferation and chemosensitivity in ovarian cancer cell lines[2]

in MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] cell viability assay in oral squamous cell carcinoma[3]

Ações bioquímicas/fisiológicas

Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca²⁺/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.

Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.

Características e benefícios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Corden. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Armazenamento e estabilidade

This product is to be stored in room temperature. Keep the product tightly closed in a well-ventilated place. Dry. Please view the Safety Data Sheet for more information.