N-Hydroxysuccinimide 98%

Sinônimo(s):

1-Hydroxy-2,5-pyrrolidinedione, HOSu, NHS

Fórmula empírica (Notação de Hill):

C₄H₅NO₃

CAS Number:

6066-82-6

Peso molecular:

115.09

Beilstein:

113913

Número CE:

228-001-3

Número MDL:

MFCD00005516

Código UNSPSC:

12352115

ID de substância PubChem:

24847975

NACRES:

NA.22

Nível de qualidade

200

Ensaio

98%

Formulário

solid

pf

95-98 °C (lit.)

grupo funcional

imide

cadeia de caracteres SMILES

ON1C(=O)CCC1=O

InChI

1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2

chave InChI

NQTADLQHYWFPDB-UHFFFAOYSA-N

Aplicação

N-Hydroxysuccinimide can be used in the synthesis of N-hydroxysuccinimide ester via dehydration reaction in the presence of dicyclohexylcarbodiimide in carboxylic acid.[1]

N-Hydroxysuccinimide has been used in the synthesis of intermediates such as:

• N

• -succinimidyl 3-(di-tert-butylfluorosilyl)benzoate[2]

• 4-[2,2-bis[(p-tolylsulfonyl)-methyl] acetyl]benzoic acid-NHS ester[3]

• N-succinimidyl 3-iodobenzoate[4]

It has also been used in a protocol for the surface modification of microchannels of a microfluidic-integrated surface plasmon resonance (SPR) platform for the detection and quantification of bacterial pathogens.[5]

Additive used in the carbodiimide method for improved amidations[6] and peptide couplings.[7]