Myricetin

≥96.0%, crystalline

Sinônimo(s):

3,3′,4′,5,5′,7-Hexahydroxyflavone, Cannabiscetin, Myricetol

About This Item

Fórmula empírica (Notação de Hill):

C₁₅H₁₀O₈

CAS Number:

529-44-2

Peso molecular:

318.24

Beilstein:

332331

Número CE:

208-463-2

Número MDL:

MFCD00006827

Código UNSPSC:

12352202

ID de substância PubChem:

24278566

NACRES:

NA.77

Nível de qualidade

100

Ensaio

≥96.0%

Formulário

crystalline

pf

>300 °C (lit.)

solubilidade

absolute ethanol: 10 mg/mL, clear to slightly hazy, yellow to very deep greenish-yellow

cadeia de caracteres SMILES

Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3cc(O)c(O)c(O)c3

InChI

1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H

chave InChI

IKMDFBPHZNJCSN-UHFFFAOYSA-N

Informações sobre genes

human ... CYP1A2(1544)
mouse ... Hexa(15211)
rat ... Il4(287287), Tnf(24835)

Aplicação

Myricetin has been used:

• to investigate its effect on end product (AGE)- bovine serum albumin mediated phosphorylation of mitogen-activated protein kinase(ERK1) [1]

• as a standard for the quantification of phenolics from noni plant extracts using high performance liquid chromatography(HPLC)[2]

• as a standard for characterization of phenolic compounds from Hibiscus sabdariffa using ultra-high performance liquid chromatography(UHPLC)[3]

Ações bioquímicas/fisiológicas

Myricetin is a naturally occurring flavonol with antioxidant property. It displays moderate membrane permeability and it degrades rapidly at elevated pH.[4] Myricetin is one of the major flavonoid present in edible plants and has anticarcinogenic and antimutagenic functionality.[5] It comprises of two benzene rings A and B. Ring B intercalates with nucleotide staking and inhibits bacterial DNA synthesis.[6] Myricetin elicits protective function against oxidative stress generated by tert-butylhydroperoxide (t-BHP) in diabetic rat and improves glutathione peroxidase (GPx) and xanthine oxidase (XO) enzyme activity. It also lowers the glycation of low-density lipoprotein.[1]