Rhynchophylline

From Uncaria rhynchophylla, ≥95% (HPLC), NMDA receptor antagonist, powder

Sinônimo(s):

(αE,1′R,6′R,7′S,8′aS)-6′-Ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo- Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid methyl ester, (7β,16E,20α)-16,17-Didehydro-17-methoxy-2-oxo-corynoxan-16-carboxylic acid methyl ester, Mitrinermin, NSC 21731, Rhynchophyllin, Rhyncophylline, Mitrinermine

Sobre este item

Fórmula empírica (Notação de Hill):

C₂₂H₂₈N₂O₄

Número CAS:

76-66-4

Peso molecular:

384.47

Número MDL:

MFCD00221748

Código UNSPSC:

12352200

NACRES:

NA.77

Nome do produto

Rhynchophylline, ≥95% (HPLC)

fonte biológica

Uncaria rhynchophylla

Ensaio

≥95% (HPLC)

Formulário

powder

cor

white to beige

solubilidade

DMSO: 2 mg/mL, clear (warmed)

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

N21[C@H]([C@@]3(CC2)c4c(cccc4)NC3=O)C[C@@H]([C@H](C1)CC)\C(=C/OC)\C(=O)OC

InChI

1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22+/m0/s1

chave InChI

DAXYUDFNWXHGBE-KAXDATADSA-N

Ações bioquímicas/fisiológicas

Rhynchophylline is a spirocyclic alkaloid isolated from Uncaria species that exibits numerous pharmacological activities including hypotensive, neuroprotective, anticonvulsive, antiepileptic, antiarrhythmic, anticoagulant, antispasmodic, and sedative. Rhynchophylline modulates voltage-gated K+ (Kv) channel slow inactivation in mouse neuroblastoma N2A cells. Also it acts as noncompetitive antagonists of NMDA receptor channels in Xenopus oocytes.