Dacarbazine antineoplastic purine analog

Sinônimo(s):

5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide, DTIC

Sobre este item

Fórmula empírica (Notação de Hill):

C₆H₁₀N₆O

Número CAS:

4342-03-4

Peso molecular:

182.18

Número CE:

224-396-1

Número MDL:

MFCD00057167

Código UNSPSC:

51102829

ID de substância PubChem:

24893683

NACRES:

NA.85

Formulário

powder or crystals

solubilidade

1 M HCl: 50 mg/mL

espectro de atividade do antibiótico

neoplastics

Modo de ação

DNA synthesis | interferes

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CN(C)\N=N\c1[nH]cnc1C(N)=O

InChI

1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+

chave InChI

FDKXTQMXEQVLRF-ZHACJKMWSA-N

Aplicação

Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents.

Ações bioquímicas/fisiológicas

Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis.[1] It is known to induce hepatotoxicity in mice.[2] Dacarbazine is not cell cycle-phase specific.

Outras notas

Keep container tightly closed in a dry and well-ventilated place.