Adenina 99% - 5 Gr - Sigma
Código: 25176
Adenina
≥99%, synthetic, powder
Sinônimo(s):
6-aminopurina, Vitamina B4
Sobre este item
Fórmula empírica (Notação de Hill):
C5H5N5
Número CAS:
Peso molecular:
135.13
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
200-796-1
MDL number:
Beilstein/REAXYS Number:
5777
Assay:
≥99%
Biological source:
synthetic
Form:
powder
Solubility:
0.5 M HCl: soluble 20 mg/mL, Grade III, colorless to faint yellow or tan
Storage temp.:
room temp
Nome do produto
Adenina, ≥99%
InChI key
GFFGJBXGBJISGV-UHFFFAOYSA-N
InChI
1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)
SMILES string
Nc1ncnc2[nH]cnc12
biological source
synthetic
assay
≥99%
form
powder
technique(s)
UV/Vis spectroscopy: suitable
color
white to off-white
mp
>360 °C (lit.)
solubility
0.5 M HCl: soluble 20 mg/mL, Grade III, colorless to faint yellow or tan
storage temp.
room temp
Quality Level
Gene Information
human ... AKT1(207), GSK3B(2932), LCK(3932), MAP3K1(4214), MAPK14(1432), MAPK8(5599), MAPK9(5601), MAPKAPK2(9261), PRKACA(5566), PRKCA(5578), RAF1(5894), ROCK2(9475)
mouse ... Mapk1(26413)
rat ... Camk2a(25400), Mapk10(25272)
Application
Adenine is suitable for use:
as a component of boron-deficient media to grow yeast in order to assess whether yeast growth is stimulated by boron[1]
as a food supplement for adult rats to investigate the effects of dietary adenine overload[2]
as a nucleic acid base supplement in the basal media used to grow anaerobic Bacillus mojavensis and Bacillus subtilis in a study to show that DNA or deoxyribonucleosides are required for the anaerobic growth of these bacteria[3]
as an additive to investigate the effects of adenine on CH4 production and on fermentation by ruminal batch cultures from nonlactating Holstein cows[4]
as a part of adenine diet in rats in a study to identify blood markers for early stages of adenine-induced chronic kidney disease (CKD)[5]
Biochem/physiol Actions
Adenine is essential for many in vivo and in vitro biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP.[6] ATP is the energy currency of the cell and is required during cellular metabolism.[7] Adenine is metabolized to is 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease (CKD) with severe anemia in rats.[8] Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds.
General description
Adenine is a purine nucleobase.[6] It is part of DNA,[6] and RNA.[9] Adenine is also a component of cofactors (NAD, FAD) and signaling molecules (cAMP).
