Ferrostatin-1 ≥95% (HPLC), powder, non-apoptotic cell death inhibitor

Sinônimo(s):

3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;

Sobre este item

Fórmula empírica (Notação de Hill):

C₁₅H₂₂N₂O₂

Número CAS:

347174-05-4

Peso molecular:

262.35

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

powder

Nome do produto

Ferrostatin-1, ≥95% (HPLC)

Quality Segment

100

assay

≥95% (HPLC)

form

powder

color

, faint purple to brown

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

N(C2CCCCC2)c1c(cc(cc1)C(=O)OCC)N

InChI

1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3

InChI key

UJHBVMHOBZBWMX-UHFFFAOYSA-N

Application

Ferrostatin-1 has been used to determine its inhibitory effect on the cell death profiles.[1]

Biochem/physiol Actions

Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis.

Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis. Ferrostatin-1 prevents ferroptopic cell death in cancer cells and glutamate-induced toxicity in organotypic rat brain slices. It appears that Ferrostatin-1 controls lipid soluble ROS.

Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.