Menadione

meets USP testing specifications

Sinônimo(s):

2-Methyl-1,4-naphthoquinone, Vitamin K₃

Sobre este item

Fórmula empírica (Notação de Hill):

C₁₁H₈O₂

Número CAS:

58-27-5

Peso molecular:

172.18

UNSPSC Code:

12352205

NACRES:

NA.21

PubChem Substance ID:

24897335

EC Number:

200-372-6

Beilstein/REAXYS Number:

1908453

MDL number:

MFCD00001681

Propriedades

biological source

synthetic (organic)

Quality Segment

200

agency

USP/NF, meets USP testing specifications

assay

98.5-101.0% dry basis

form

solid

mp

105-107 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

CC1=CC(=O)c2ccccc2C1=O

InChI

1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3

InChI key

MJVAVZPDRWSRRC-UHFFFAOYSA-N

Gene Information

human ... NQO1(1728)

Descrição

General description

Menadione (Vitamin K3) is the synthetic form of vitamin K. It has the structure similar to vitamin K1 and K2. Vitamin K1, K2 and K3 are biologically active. Water soluble forms of menadiones are used in swine and poultry diets.

Application

Menadione has been used:

• to treat HL-60 cells as positive control for apoptosis for flow cytometry

• as an oxidative stress inducer in transgenic embryos after 24 h of post fertilization

• to treat HaCaT cell line, for quantifying total and oxidised glutathione

Biochem/physiol Actions

Menadione is an oxidative stress inducer.