7,12-Dimethylbenz [a] Anthracene 95% - 100 Mg - Sigma
Código: 17615
Sinônimo(s):
DMBA, 1,4-Dimethyl-2,3-benzophenanthrene, 9,10-Dimethyl-1,2-benzanthracene
Empirical Formula (Hill Notation):
C20H16
Número CAS:
Peso molecular:
256.34
Beilstein:
1912135
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.25
Nível de qualidade
200
teor
≥95%
forma
powder
pf
122-123 °C (lit.)
SMILES string
Cc1c2ccccc2c(C)c3c1ccc4ccccc34
InChI
1S/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3
InChI key
ARSRBNBHOADGJU-UHFFFAOYSA-N
Descrição geral
7,12-Dimethylbenz[a]anthracene belongs to the category of polycyclic aromatic hydrocarbons. It is a carcinogenic organic pollutant generated from the incomplete combustion of gasoline and coal.
Aplicação
7,12-Dimethylbenz[a]anthracene was used:
to study the effects of Cimicifuga racemosa (CR) extract on the growth of mammary tumor induced by 7,12-Dimethylbenz[a]anthracene
in the study to compare the anti-carcinogenic properties of four red wine polyphenols as an initiator to cause skin cancer in CD-1 mouse model
to induce epithelial carcinogenicity in order to study the apoptotic, proliferating and p12doc-1 profiles of normal, hyperplastic, dysplastic and malignant oral epithelium in the cheek pouch of the Syrian hamster
to cause mammary tumors to examine the causes and prevention of triacylglycerol accumulation in rat liver due to tamoxifen
Embalagem
100 mg in glass bottle
1, 5 g in glass bottle
Ações bioquímicas/fisiológicas
7,12-Dimethylbenz[a]anthracene has been found to be cytotoxic in nature, having carcinogenic properties. It also shows selective necrosis and hemorrhaging in the adrenal gland along with an inhibitory effect on plasma alkaline phosphatase levels. Its damaging effects are due to its ability to form charge transfer complexes by donating electrons to appropriate electron acceptors.